Peter W Stacpoole Selected Research

Investigational Drugs

11/2020	Effects of Multiple Doses of Dichloroacetate on GSTZ1 Expression and Activity in Liver and Extrahepatic Tissues of Young and Adult Rats.
1/2020	Pharmacokinetic and Biochemical Profiling of Sodium Dichloroacetate in Pregnant Ewes and Fetuses.
1/2018	Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1.
1/2018	Model Informed Dose Optimization of Dichloroacetate for the Treatment of Congenital Lactic Acidosis in Children.
1/2016	Pharmacogenetic considerations with dichloroacetate dosing.
4/2015	Chloride concentrations in human hepatic cytosol and mitochondria are a function of age.
12/2013	Pharmacokinetics of oral dichloroacetate in dogs.
2/2012	Prenatal and postnatal expression of glutathione transferase ζ 1 in human liver and the roles of haplotype and subject age in determining activity with dichloroacetate.
10/2008	Role of dichloroacetate in the treatment of genetic mitochondrial diseases.
9/2008	The heme precursor delta-aminolevulinate blocks peripheral myelin formation.

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Peter W Stacpoole Research Topics

Disease

14	Mitochondrial Diseases (Mitochondrial Disease) 01/2021 - 02/2006
13	Lactic Acidosis 01/2020 - 04/2003
11	Neoplasms (Cancer) 11/2020 - 03/2005
5	Peripheral Nervous System Diseases (PNS Diseases) 01/2019 - 02/2006
5	Pyruvate Dehydrogenase Complex Deficiency Disease 04/2018 - 05/2006
4	Sepsis (Septicemia) 01/2022 - 01/2018
4	Inflammation (Inflammations) 01/2022 - 02/2006
3	Liver Neoplasms (Liver Cancer) 01/2017 - 11/2009
3	Metabolic Diseases (Metabolic Disease) 01/2016 - 03/2008
3	Cardiovascular Diseases (Cardiovascular Disease) 10/2012 - 11/2004
3	Tyrosinemias (Tyrosinemia) 09/2008 - 09/2004
2	Body Weight (Weight, Body) 01/2018 - 05/2006
2	Infections 11/2009 - 07/2007
2	Hyperhomocysteinemia 05/2005 - 02/2004
2	Insulin Resistance 04/2004 - 03/2003
2	Malaria 10/2003 - 04/2003
1	Dyslipidemias (Dyslipidemia) 01/2022
1	Hypoglycemia (Reactive Hypoglycemia) 01/2022
1	Anorexia 01/2022
1	Shock 01/2020
1	Myocardial Ischemia (Ischemic Heart Diseases) 01/2020
1	Vitamin B 6 Deficiency (Pyridoxine Deficiency) 07/2016
1	Hepatocellular Carcinoma (Hepatoma) 06/2016
1	Neoplasm Metastasis (Metastasis) 12/2014
1	Melanoma (Melanoma, Malignant) 12/2014
1	Vascular Remodeling 12/2014
1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders) 12/2014
1	Astrocytoma (Pilocytic Astrocytoma) 12/2014
1	Pulmonary Arterial Hypertension 12/2013
1	Vascular Diseases (Vascular Disease) 11/2013
1	Inborn Genetic Diseases (Disease, Hereditary) 03/2013
1	Inborn Errors Metabolism (Inborn Errors of Metabolism) 03/2013
1	Hypoxia (Hypoxemia) 11/2011
1	Porphyrias (Porphyria) 09/2008
1	Wounds and Injuries (Trauma) 05/2006

Drug/Important Bio-Agent (IBA)

13	Investigational DrugsIBA 11/2020 - 07/2003
9	Pyruvate Dehydrogenase Complex (Dehydrogenase Complex, Pyruvate)IBA 10/2019 - 06/2006
8	Lactic Acid (Lactate)FDA LinkGeneric 01/2020 - 04/2003
5	Glutathione Transferase (Glutathione S-Transferase)IBA 04/2018 - 02/2012
5	VitaminsIBA 01/2015 - 02/2004
4	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 03/2003
4	Pyruvic Acid (Pyruvate)IBA 07/2012 - 07/2007
4	Tyrosine (L-Tyrosine)FDA Link 02/2012 - 09/2004
4	HomocysteineIBA 02/2006 - 02/2004
3	Pyruvate Dehydrogenase Acetyl-Transferring KinaseIBA 01/2022 - 11/2017
3	Proteins (Proteins, Gene)FDA Link 06/2016 - 01/2008
3	EnzymesIBA 06/2016 - 02/2004
3	LipidsIBA 10/2012 - 03/2003
2	Amino Acids FDA Link 01/2022 - 01/2020
2	CarbohydratesIBA 01/2022 - 04/2004
2	Tricarboxylic AcidsIBA 01/2021 - 01/2020
2	Biomarkers (Surrogate Marker)IBA 01/2020 - 01/2015
2	Dichloroacetic AcidIBA 01/2020 - 02/2012
2	Cysteine (L-Cysteine)FDA Link 07/2016 - 02/2006
2	ChloridesIBA 06/2016 - 04/2015
2	CarbonIBA 01/2015 - 02/2004
2	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2014 - 11/2009
2	DNA (Deoxyribonucleic Acid)IBA 12/2014 - 11/2014
2	CaspasesIBA 12/2014 - 11/2009
2	Mitochondrial DNA (mtDNA)IBA 11/2014 - 05/2006
2	Oxidoreductases (Dehydrogenase)IBA 10/2010 - 07/2007
2	C-Reactive ProteinIBA 02/2006 - 11/2004
2	Folic Acid (Vitamin M)FDA LinkGeneric 05/2005 - 02/2004
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2022
1	Nonesterified Fatty Acids (NEFA)IBA 01/2022
1	itaconic acidIBA 01/2020
1	Branched-Chain Amino AcidsIBA 01/2020
1	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA 01/2019
1	AntioxidantsIBA 01/2019
1	Glutathione (Reduced Glutathione)IBA 01/2018
1	CarcinogensIBA 01/2017
1	CystathionineIBA 07/2016
1	glyoxylic acid (glyoxylate)IBA 06/2016
1	Tryptophan (L-Tryptophan)FDA Link 01/2015
1	Oral ContraceptivesIBA 01/2015
1	PlatinumIBA 12/2014
1	PyridoxalIBA 11/2013
1	Coenzymes (Enzyme Cofactors)IBA 11/2012
1	maleylacetoacetate isomeraseIBA 02/2012
1	AcidsIBA 02/2012
1	Transcription Factors (Transcription Factor)IBA 11/2011
1	Oxygen (Dioxygen)IBA 11/2009
1	alpha-Fetoproteins (alpha-Fetoprotein)IBA 11/2009
1	pyruvate dehydrogenase E1alpha subunitIBA 11/2009
1	Aminolevulinic Acid (Levulan)FDA Link 09/2008
1	Heme (Haem)IBA 09/2008
1	Pharmaceutical PreparationsIBA 05/2008
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2008
1	Messenger RNA (mRNA)IBA 07/2007
1	Dihydrotachysterol (AT 10)IBA 07/2007
1	fumarylacetoacetase (fumarylacetoacetate hydrolase)IBA 05/2006
1	cysteinylglycine (Cys-Gly)IBA 02/2006
1	Adenosine Triphosphate (ATP)IBA 02/2006

Therapy/Procedure

8	Therapeutics 01/2020 - 09/2009
2	Punctures 01/2022 - 01/2021
2	Ligation 01/2022 - 01/2021
2	Ketogenic Diet 06/2013 - 04/2004
1	Intraperitoneal Injections 01/2022
1	Investigational Therapies (Experimental Therapy) 12/2014
1	Hepatectomy 03/2013